FACIAL TRIANGLE
By ; Dr AMY BARRETO DIAZ, April 25/2024
Stem cells are the raw material of the human body and their main function is to maintain and repair the tissue in which they are found. Stem cells can generate healthy cells to replace cells affected by disease. Stem cells are a potential therapy for revascularization due to their self-renewal capacity, their relatively easy isolation, and their ability to migrate to ischemic tissues," the authors of this experiment note in the pages of 'Proceedings of the National Academy of Sciences'.
Diseases of high prevalence and high morbidity and mortality for which there are currently no treatments available for these devastating diseases and consequently have generated great expectations. However, for these perspectives to become a reality, it is necessary to continue preclinical research for stem cell-mediated therapy, and in parallel to continue translational studies in the context of clinical trials, carried out according to internationally valid standards.
Neurodegenerative diseases affect various activities that the body performs, such as balance, movement, speaking, breathing, and heart functions. Many of these diseases are genetic. The causes may be alcoholism, a tumor or a cerebrovascular attack (CVA). Other causes include toxins, chemicals and viruses. Other times, the causes are unknown.
Some neurodegenerative diseases are:
Alzheimer disease
Amyotrophic Lateral Sclerosis
Friedreich's ataxia
Huntington's disease
Dementia with Lewy bodies
Parkinson's disease
spinal muscular atrophy
Neurodegenerative diseases can be serious or life-threatening. It depends on the type. Most of them have no cure. Treatment can help improve symptoms, relieve pain, and increase mobility.
Although much progress has been made in the knowledge of the mechanisms underlying therapy with adipose-derived stem cells, and in its translation to the clinic, there are still many questions to be resolved, such as treatments, approach, and clinical and therapeutic indications.
Adult stem cells, particularly those derived from adipose cells, do not pose ethical problems, are easily accessible, are safe, and their autologous use does not generate rejection. They are capable of surviving in the central nervous system, migrating to the injured area and, in some cases, acquiring morphology and neural markers.
Stem Cells improve the conditions for the arrival of blood by increasing the diameter of arterial vessels, favoring the formation of new blood vessels. Generate an inflammatory environment that facilitates repair around the injury. Increase the turgor and elasticity of the walls of the veins to optimize blood return and thus avoid edema and the accumulation of toxins. Provide cells that can replace missing tissue.
Its mechanism of action remains to be clarified but phenomena of gene reprogramming and damaged neural microenvironment have been invoked. Stem cells can produce a regenerating effect on damaged neural cells, decreasing their apoptosis and stimulating a microenvironment of the central nervous system with positive and synergistic effects for the repair of cellular damage.
Craniotomy and other invasive surgeries are currently used to cross the blood-brain barrier, but techniques based on ultrasonography and new biomaterials are being explored that allow the permeability of this barrier to be increased reversibly in a specific area.
One of the most key and innovative aspects includes the methods and pathways for releasing stem cells for neural pathologies with minimally invasive procedures. The investigation of new migratory routes such as intranasal or the study of other non-invasive methods.
Currently, the most advanced methods and pathways for releasing stem cells are minimally invasive in the intranasal area.
POSSIBLE USE OF STEM CELLS DERIVED FROM ADIPOSITES IN NEURODEGERATIVE PATHOLOGIES WITH MINIMALLY INVASIVE LIPOINJECTION METHODS VIA Naso-Genial-Labial Triangle.
Naso-Genial-Labial Triangle is the area of our body, it is the part that begins at the bridge of the nose and goes down to the corner of the lips, closing just at the lower lip, which forms a triangle around the nose. .
One of the main characteristics of this facial area is venous return of blood in said territory, which occurs through a superficial vein called the angular vein, which, starting from the corners of the mouth, extends along the entire nasal wing. to finally end up, after penetrating the interior of the skull through the internal angle of the eye and the orbital cavity, to the cavernous sinus. This area that is in the center of the head in the area of the base of the skull is known as the cavernous sinus and is a vascular cistern that collects drained blood and is located in the thickness of the brain. It is a vein without valves that reaches the brain, nerves, veins and arteries that go to the eye, muscles pass through the cavernous sinus and it is also in close relationship with the pituitary gland, meninges that cover the brain.
In my opinion, as a Surgeon, analyzing the facial anatomy, I believe that another less invasive therapeutic alternative is possible, which would be Lipoinjection of stem cells derived from adipocytes in the Naso-Genial-Labial Triangle area, since it has high vascular irrigation, which is conducive to mechanical treatment. effective functioning of stem cells derived from adipose cells, this area allows us to locate and address the treatment in the neural area and overcome the blood-brain barrier without performing a major procedure, without trauma or surgical complexity, also in a safe way and without possible effects. secondary. A craniotomy and other invasive surgeries to cross the blood-brain barrier would be avoided.
New studies and advances in treatment of adult stem cells and their combination;
Stem cell activation
Micro injuries in specific area to treat.
Previous Treatment to increase Effector Leukocytes
Minimally invasive procedures for the release of stem cells and minimally invasive in the intranasal area. neural pathologies. In a safe way and without possible side effects.
Nanofat can be a useful technique since it does not generate volume in the application area.
Proven benefits Stem cells
Stem Cells improve the conditions for the arrival of blood by increasing the diameter of arterial vessels, favoring the formation of new blood vessels.
Generate an inflammatory environment that facilitates repair around the injury.
Increase the turgor and elasticity of the walls of the veins to optimize blood return and thus avoid edema and the accumulation of toxins.
Provide cells that can replace missing tissue.
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